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KMID : 0352720070310020074
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Journal of Ginseng Research
2007 Volume.31 No. 2 p.74 ~ p.78
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Effects of Non-Saponin Red Ginseng Components on Multi-drug Resistance
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Kim Eun-Hye
Park Jong-Dae
Pyo Suhk-Neung
Rhee Dong-Kwon
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Abstract
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Multi-drug resistance (MDR) is a major problem in cancer chemotherapy and has often ended up with termination of the therapy. The aim of this study was to identify any fractions of Korean red ginseng that would be effective in modulating for MDR. Although ginsenosides have been reviewed as possible MDR modulators, the MDR modulation activity of the other component is unknown. Therefore, a red ginseng was extracted with methanol, ether, ethylacetate, and n-butanol, followed by several fractionations by silica gel chromatography. And the activity of MDR modulating for these fractions was examined via sulforrhodamine B assay. We have found that several ether fractions, as nonsaponin components are effective on MDR modulation. We have expect that these results helpful to improvement of cancer chemotherapy
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KEYWORD
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Red ginseng, multi-drug resistance, multi-drug related protein, MDR, MRP
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